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fosphenytoin will lessen the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.crofelemer raises levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the opportunity to inhibit CYP3A4 at concentrations predicted during the int